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Metformin and Polycystic Ovarian Syndrome

"PCOS often presents in adolescence, with irregular menstrual cycles, acne, or too much body hair," said the study’s senior author, Lourdes Ibáñez, MD, PhD, professor of pediatrics at the University of Barcelona in Spain and lead author of the study. "But we believe the critical years for PCOS development may be during childhood and puberty when excessive amounts of fat are stored. That excessive weight gain overexposes the ovaries to insulin, causing them to stop ovulating and start releasing male hormones, resulting in PCOS."

In this study of 38 girls with low birth-weight and early puberty, researchers compared the efficacy of early versus late metformin treatment to prevent adolescent PCOS. A group of 19 8-year-old girls were treated with daily doses of metformin for four years. A second group of 19 girls waited five years before they began receiving daily doses of metformin at age 13 and then continued treatment for only one year. They found that early metformin therapy prevented or delayed the development of hirsutism, androgen excess and PCOS more effectively than late metformin treatment.”

This is a small study, but it’s interesting because I had no idea PCOS had anything to do with insulin or androgens. The more you know!

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